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Updated: Dec 8, 2025

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
Published on: March 28, 2018
[; ADAPTATION OF THE BILE DUCTS OF THE PORTAL TRIAD IN CASE OF MECHANICAL CHOLESTASIS (REVIEW)]
I Chanukvadze1, L Kikalishvili1, K Jandieri1
1Tbilisi State Medical University, Department of General Surgery; Department of Clinical Anatomy and Operative Surgery,Georgia.
Abstract:
In case of mechanical cholestasis, along with stagnation in the veins and bile ducts, lymph production increases, which contributes to the accumulation of ascitic fluid. In the peribiliaryareas, where the extramural biliary glands are located, an accumulation of lymphatic vessels has been observed in all the preparations.In these same areas, a contrast-enhanced microtomography showed transition of the ink-gelatin contrast agents (using gelatin and India ink) from the extramural part of the mucous glands to the lumen of the lymphatic capillaries and blood vessels.Lymphobiliary connections were visualized during the preparation of the sections of the portal triad of the lobar and sectoral portal tracts under a binocular microscope. More reliable evidence of the existence of lymphobiliary connections in the portal triad region was revealed on histological preparations stained with traditional methods.; Thus, anatomically, the area of the portal triad appears to be one of the alternative areas of lymphobiliary communications, which further confirms its high adaptive capacity in case of stagnation of bile.

