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Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
Published on: March 28, 2018
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[; ADAPTATION OF THE BILE DUCTS OF THE PORTAL TRIAD IN CASE OF MECHANICAL CHOLESTASIS (REVIEW)]
I Chanukvadze1, L Kikalishvili1, K Jandieri1
1Tbilisi State Medical University, Department of General Surgery; Department of Clinical Anatomy and Operative Surgery,Georgia.
Georgian Medical News
|September 23, 2020
Summary
Mechanical cholestasis increases lymph production, leading to fluid buildup. This study reveals lymphobiliary connections in the portal triad, offering an alternative pathway for bile flow during stagnation.
Area of Science:
- Gastroenterology
- Hepatology
- Anatomy
Background:
- Mechanical cholestasis causes bile duct stagnation and increased lymph production, contributing to ascites.
- The peribiliary areas contain extramural biliary glands and lymphatic vessels.
Purpose of the Study:
- To investigate the existence and anatomical location of lymphobiliary connections.
- To understand the role of these connections in mechanical cholestasis.
Main Methods:
- Contrast-enhanced microtomography using ink-gelatin contrast agents.
- Microscopic examination of portal triad sections under a binocular microscope.
- Histological preparations stained with traditional methods.
Main Results:
- Accumulation of lymphatic vessels observed in peribiliary areas with extramural biliary glands.
- Ink-gelatin contrast agents transitioned from mucous glands to lymphatic capillaries and blood vessels.
- Lymphobiliary connections were visualized in the portal triad region.
Conclusions:
- The portal triad region serves as an alternative site for lymphobiliary communications.
- These connections demonstrate adaptive capacity in managing bile stagnation during cholestasis.
