Related Experiment Video
Updated: Feb 15, 2026

08:58
Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device
Published on: December 25, 2015
16.7K
Determination of the optimum double-pass image through focus operators
Summary
Tenengrad variance and Gray level local variance autofocus operators best identify optimal double-pass images. These autofocus operators effectively detect focus lines and disc of least confusion in astigmatic eyes.
Area of Science:
- Ophthalmic optics
- Image analysis
- Visual optics
Background:
- Accurate assessment of optical quality is crucial for understanding visual function.
- Double-pass systems provide detailed information about image quality.
- Autofocus operators (AFO) and optical quality parameters (OQP) are used to analyze these images.
Purpose of the Study:
- To evaluate the effectiveness of various autofocus operators (AFO) in determining optimal double-pass images.
- To assess the capability of AFOs in detecting focus lines and the disc of least confusion in astigmatic eyes.
- To compare the performance of different AFOs and OQPs using a maximum discrimination (MD) parameter.
Main Methods:
- Eight AFOs and three OQPs were analyzed.
- A maximum discrimination (MD) parameter was introduced to quantify performance.
- Double-pass images were acquired from an artificial eye (with and without astigmatism) and 19 human eyes.
Main Results:
- Tenengrad variance and Gray level local variance showed the highest MD values for both astigmatic and non-astigmatic artificial eyes.
- Tenengrad variance demonstrated superior discrimination of focus lines in astigmatic eyes compared to OQPs.
Conclusions:
- Autofocus operators, specifically Tenengrad variance and Gray level local variance, are highly effective for analyzing double-pass images.
- Tenengrad variance shows promise for accurately characterizing optical aberrations, particularly in astigmatic conditions.
Related Concept Videos
First Pass Effect
9.7K
Presystemic elimination, or the first-pass effect, is the metabolism of drugs that reduces their effective concentration at the site of action. Apart from the first-pass effect, the systemic bioavailability of the drug is also reduced by other factors, including incomplete absorption or chemical degradation of drugs.
Depending on the route of administration, drugs can be metabolized in the liver, intestine, lungs, and vasculature. Orally administered drugs are first absorbed through the...
Depending on the route of administration, drugs can be metabolized in the liver, intestine, lungs, and vasculature. Orally administered drugs are first absorbed through the...
9.7K
Single-pass Transmembrane Proteins
6.8K
Integral membrane proteins are tightly associated with the cell membrane and play a crucial role in cell communication, signaling, adhesion, and transport of the molecules. Some integral membrane proteins are present only in the membrane monolayer. For example, the enzyme fatty acid amide hydrolase is present in the cytoplasmic side of the membrane monolayer. In contrast, another type of integral membrane protein, also known as a transmembrane protein, spans across the membrane. Transmembrane...
6.8K
Factors Influencing Bioavailability: First-Pass Elimination
8.2K
When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
8.2K
Real Number Operations
349
The concept of real numbers includes all the values that can be represented on a continuous number line. The system began with basic counting values used for enumeration. It later expanded to include values that represent the absence of quantity and opposites of the counting values. When situations required expressing parts of a whole or dividing quantities evenly, values capable of representing such proportions were developed. When written using decimal notation, these values can end or repeat...
349
Operational Amplifiers
2.0K
The operational amplifier, often referred to as an op-amp, is a multifaceted building block of a circuit. This electronic component functions like a voltage-controlled voltage source and can also be used to create a voltage- or current-controlled current source. The design of an operational amplifier enables it to execute mathematical operations when external components like resistors and capacitors are linked to its terminals. An op-amp has the capacity to sum signals, amplify a signal,...
2.0K
Insertion of Single-pass Transmembrane Proteins in the RER
18.2K
Integral membrane proteins are proteins adhered to the lipid bilayer of a cell organelle or membrane. They can be of two types: transmembrane integral proteins that span the lipid bilayer and monotopic proteins that are attached to either side of the membrane but do not pass through it.
Integral transmembrane proteins possess transmembrane and extra membrane domains. The transmembrane domains are primarily made of 20-25 hydrophobic amino acids arranged in a helical secondary confirmation. These...
Integral transmembrane proteins possess transmembrane and extra membrane domains. The transmembrane domains are primarily made of 20-25 hydrophobic amino acids arranged in a helical secondary confirmation. These...
18.2K

