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Updated: Feb 15, 2026

The Use of Chemostats in Microbial Systems Biology
Published on: October 14, 2013
On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems
Rohit T Rao1, Megerle L Scherholz1, Clara Hartmanshenn1
1Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854.
Abstract:
The use of models in biology has become particularly relevant as it enables investigators to develop a mechanistic framework for understanding the operating principles of living systems as well as in quantitatively predicting their response to both pathological perturbations and pharmacological interventions. This application has resulted in a synergistic convergence of systems biology and pharmacokinetic-pharmacodynamic modeling techniques that has led to the emergence of quantitative systems pharmacology (QSP). In this review, we discuss how the foundational principles of chemical process systems engineering inform the progressive development of more physiologically-based systems biology models.
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