Related Experiment Video
Updated: Feb 15, 2026
07:35
Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone
Published on: June 7, 2017
10.2K
New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach
Eduardo Esteves1, Nuno Rosa1, Maria José Correia1
1Universidade Católica Portuguesa, Center for Interdisciplinary Research in Health (CIIS), Institute of Health Sciences (ICS), Viseu, Portugal.
Biomed Research International
|January 31, 2018
Summary
This study identifies 18 new human targets for Zika virus (ZIKV) proteins, revealing novel entry pathways and immune evasion mechanisms. These findings are crucial for developing ZIKV vaccines and therapies.
Area of Science:
- Virology
- Immunology
- Proteomics
Background:
- Understanding Zika virus (ZIKV) tropism and pathogenesis is challenging.
- Identifying host factors ZIKV interacts with is critical for therapeutic development.
Purpose of the Study:
- To identify novel human host targets for ZIKV proteins.
- To elucidate ZIKV entry mechanisms and immune evasion strategies.
Main Methods:
- Integrated analysis of proteomic, gene expression, and predicted Protein-Protein Interactions (PPIs) using the OralInt algorithm.
- Identification of host proteins involved in vesicular traffic, endocytosis, and immune response pathways.
Main Results:
- 1898 medium to high-scoring ZIKV-human protein interactions were identified.
- New ZIKV entry receptors in clathrin-dependent (17) and independent (10) endocytosis pathways were discovered.
- 18 novel human targets for ZIKV proteins, including immune-related targets like IFN receptors and TLRs, were proposed.
Conclusions:
- This research proposes 18 new human targets for ZIKV proteins, advancing the understanding of viral pathogenesis.
- Identified targets offer potential for developing new ZIKV vaccines and therapeutics.
Related Concept Videos
00:50What are Viruses?
128.5K
Overview
128.5K
00:57Viral Recombination
25.2K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.2K
00:56Viral Structure
74.8K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.8K
00:36Viral Mutations
40.0K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
40.0K
01:22Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
228
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
228
01:20Frustration and Conflict: Approach-Approach, Approach-Avoidance
553
Frustration occurs when people are obstructed or prevented from achieving a desired goal or fulfilling a perceived need. For example, when someone's input is ignored in a discussion, it can lead to feelings of frustration. Conflict, however, arises from opposing interests, goals, or actions. Conflicts can take various forms based on the nature of these opposing desires or goals.
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
553