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Endothelial function in children with white-coat hypertension.
Alexander Jurko1, Tomas Jurko2, Milan Minarik3
1Pediatric Cardiology Clinic, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic.
Heart and Vessels
|January 31, 2018
Summary
Children with white-coat hypertension exhibit endothelial dysfunction, similar to essential hypertension. This impaired flow-mediated dilation (FMD) suggests white-coat hypertension is not benign and may carry similar cardiovascular risks.
Area of Science:
- Cardiovascular Research
- Pediatric Hypertension
- Endothelial Function Assessment
Background:
- Endothelial dysfunction is documented in essential hypertension.
- Endothelial function in pediatric white-coat hypertension remains understudied.
Purpose of the Study:
- To evaluate endothelial function in children with white-coat hypertension and essential hypertension.
- To compare endothelial function using flow-mediated dilation (FMD) in pediatric hypertensive groups and controls.
Main Methods:
- Ultrasound assessment of brachial artery flow-mediated dilation (FMD) in 106 children.
- Groups included white-coat hypertension (n=30), essential hypertension (n=30), and healthy controls (n=46).
- Deficient FMD was defined as values < 5%.
Main Results:
- Significantly lower FMD was observed in both white-coat and essential hypertension groups compared to controls (p < 0.05).
- No significant difference in FMD was found between the two hypertensive groups.
- Deficient FMD occurred significantly more often in both hypertensive groups than in controls (p < 0.01).
Conclusions:
- Pediatric white-coat hypertension is associated with endothelial dysfunction, indicated by impaired FMD.
- This dysfunction suggests similar cardiovascular risk mechanisms as in essential hypertension.
- White-coat hypertension in children should not be considered a benign condition.
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