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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Routine Screening Method for Microparticles in Platelet Transfusions
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[HEV and transfusion-recipient risk].

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Annales Pharmaceutiques Francaises
|February 4, 2018
PubMed
Summary
This summary is machine-generated.

Hepatitis E virus (HEV) can spread through blood transfusions, posing risks for severe liver disease and chronic infections, especially in immunocompromised individuals. Blood safety measures are crucial to mitigate transfusion-transmitted HEV risks globally.

Keywords:
Blood donorsBlood safetyDonneurs de sangGenotype 3Génotype 3HEVSécurité transfusionnelleTransfusionVHE

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Transfusion Medicine

Background:

  • Hepatitis E virus (HEV) is primarily food- and water-borne, but transfusion transmission is a recognized route in both developing and developed nations.
  • While often asymptomatic, HEV infection can cause severe outcomes like fulminant hepatitis in specific populations and chronic hepatitis E in immunocompromised individuals.
  • Extra-hepatic manifestations, including neurological and renal complications, have been documented, highlighting the systemic impact of HEV.

Purpose of the Study:

  • To review the epidemiology and risks associated with transfusion-transmitted Hepatitis E virus (HEV) infections.
  • To discuss the factors influencing HEV transmission through blood products.
  • To highlight the importance of blood safety measures in response to HEV prevalence.

Main Methods:

  • Literature review of HEV transmission routes, clinical manifestations, and risk factors.
  • Analysis of epidemiological data concerning HEV prevalence in blood donors.
  • Examination of existing and potential blood safety strategies.

Main Results:

  • Transfusion-transmitted HEV is a significant concern, with transmission occurring globally.
  • Risk is associated with donor viremia frequency, viral load, and transfused plasma volume.
  • Developed countries are implementing HEV-specific blood safety measures based on epidemiological data.

Conclusions:

  • Hepatitis E virus poses a transfusion risk that necessitates robust blood safety protocols.
  • Understanding HEV epidemiology in blood donors is essential for effective prevention strategies.
  • Continued vigilance and adaptation of blood screening and safety measures are required to protect recipients from HEV infection.