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Regulating β-Catenin Nuclear Import with the Small GTPase Rap

Naoko Imamoto1

  • 1Cellular Dynamics Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Developmental Cell
|February 6, 2018
PubMed
Summary

The nuclear import of beta-catenin (a key Wnt signaling mediator) is actively regulated by the small GTPase Rap and its guanine nucleotide exchange factor, RAPGEF5. This finding reveals a novel regulatory mechanism for Wnt pathway activation.

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