Nrf2s Take the Upper Hand in the Upper Jaw.
1Centre for Craniofacial and Regenerative Biology, Department of Craniofacial Development and Stem Cell Biology, King's College London, London SE1 9RT, UK.
Developmental Cell
|February 7, 2018
Summary
New research reveals that Nr2f nuclear receptors are crucial for determining jaw development. These receptors control the fate of the maxilla and mandible, shaping the upper jaw in vertebrates.
Area of Science:
- Developmental biology
- Evolutionary developmental biology
- Genetics
Background:
- Jaw development in vertebrates is a complex process involving the formation of distinct upper (maxilla) and lower (mandible) jaws.
- Understanding the genetic mechanisms that regulate craniofacial development is essential for insights into vertebrate evolution.
Purpose of the Study:
- To investigate the role of Nr2f nuclear receptors in the specification of maxilla versus mandible.
- To elucidate the molecular mechanisms underlying upper jaw formation in jawed vertebrates.
Main Methods:
- Utilized genetic analysis in model organisms.
- Investigated the expression patterns and functions of Nr2f nuclear receptors during craniofacial development.
Main Results:
- Identified Nr2f nuclear receptors as key regulators of jaw element identity.
- Demonstrated that Nr2f receptors control the developmental fate between the maxilla and mandible.
- Highlighted the importance of these receptors in shaping the upper jaw structure.
Conclusions:
- Nr2f nuclear receptors play a critical role in establishing jaw asymmetry.
- These findings provide new insights into the genetic control of craniofacial evolution in jawed vertebrates.
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