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Updated: Feb 14, 2026

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
Published on: May 16, 2022
EFFECT OF FREE RADICALS ON CALCITONIN-GENE-RELATED PEPTIDE MEDIATED VASODILATION
M Dekanosidze1, K Saganelidze1, N Mitagvaria1
1New Vision University, Tbilisi; I. Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.
Abstract:
It is known that in some pathological conditions, due to the formation of a large number of free oxygen radicals, the cardiovascular system is severely affected. However, the effect of free radicals on CGRP-mediated vasodilation remains unclear. The aim of this work was to study the effect of free radicals on CGRP-mediated neurogenic vasodilation on preparations of an isolated rabbit lingual artery. The experiments were performed on the lingual artery preparations of 6 rabbits of the Chinchilla breed of both sexes. The contractile-relaxation activity of isolated preparations, both with intact endothelial layer and deendotelized, were studied in isometric mode on a strain-gauge unit using mechanotrons of the 6 MX1C type. Our experiments showed that free radicals can disrupt the reactivity of the vascular wall both in the presence and in the absence of endothelium-dependent relaxation factors and that is might be considered as a main conclusion of this study.
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