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Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
Published on: May 16, 2022
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EFFECT OF FREE RADICALS ON CALCITONIN-GENE-RELATED PEPTIDE MEDIATED VASODILATION
M Dekanosidze1, K Saganelidze1, N Mitagvaria1
1New Vision University, Tbilisi; I. Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.
Georgian Medical News
|February 21, 2018
Summary
Free radicals negatively impact cardiovascular function by disrupting vascular wall reactivity. This study reveals that free radicals impair calcitonin gene-related peptide (CGRP)-mediated vasodilation, affecting blood vessel function.
Area of Science:
- Cardiovascular Physiology
- Vascular Biology
- Free Radical Biology
Background:
- Pathological conditions can lead to increased free oxygen radicals, adversely affecting the cardiovascular system.
- The specific impact of free radicals on calcitonin gene-related peptide (CGRP)-mediated vasodilation is not well understood.
- Understanding this interaction is crucial for addressing cardiovascular dysfunction.
Purpose of the Study:
- To investigate the effect of free radicals on CGRP-mediated neurogenic vasodilation.
- To examine this effect using isolated rabbit lingual artery preparations.
- To determine if free radicals alter vascular reactivity independently of endothelial factors.
Main Methods:
- Experiments were conducted on isolated lingual artery preparations from Chinchilla rabbits.
- Contractile and relaxation activities were measured isometrically using a strain-gauge unit and mechanotrons.
- Studies were performed on both intact and de-endothelialized arterial preparations.
Main Results:
- Free radicals were found to disrupt the reactivity of the vascular wall.
- This disruption occurred irrespective of the presence or absence of the endothelial layer.
- The findings indicate a direct impact of free radicals on vascular smooth muscle function.
Conclusions:
- Free radicals can impair vascular wall reactivity.
- CGRP-mediated vasodilation is susceptible to disruption by free radicals.
- These effects suggest a significant role for free radicals in cardiovascular pathology.
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