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Detection of RB1 Gene Copy Number Variations Using a Multiplex Ligation-Dependent Probe Amplification Method.

Nejat Dalay1

  • 1Oncology Institute, Istanbul University, Istanbul, Turkey. ndalay@yahoo.com.

Methods in Molecular Biology (Clifton, N.J.)
|February 23, 2018
PubMed
Summary

Multiplex ligation-dependent probe amplification (MLPA) reliably detects DNA copy number changes. This method is crucial for investigating genomic aberrations in various diseases, including analysis of the RB1 gene locus.

Keywords:
Copy number variationMultiplex ligation-dependent probe amplificationRB1 geneRetinoblastoma proteinTumor suppressor genes

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