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Multiparameter estimation using multi-echo spoiled gradient echo with variable flip angles and multicontrast

Daiki Tamada1, Tetsuya Wakayama2, Hiroshi Onishi1

  • 1Department of Radiology, University of Yamanashi, Yamanshi, Japan.

Magnetic Resonance in Medicine
|February 25, 2018
PubMed
Summary
This summary is machine-generated.

This study presents a rapid, single breath-hold MRI technique for multiparameter liver mapping. It accurately quantifies T1, R2*, and proton density fat fraction, aiding liver disease assessment.

Keywords:
imagingmagnetic resonance imagingmulti-echo spoiled gradient echo phantoms

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Medical Imaging
  • Hepatology

Background:

  • Liver disease diagnosis relies on accurate functional and structural assessment.
  • Multiparameter MRI can provide comprehensive liver evaluation.
  • Current methods often require prolonged scan times, limiting clinical utility.

Purpose of the Study:

  • To develop a novel, rapid multiparameter MRI technique for liver assessment.
  • To enable simultaneous quantitative mapping of T1, R2*, and proton density fat fraction within a single breath-hold.
  • To evaluate the feasibility and accuracy of this approach for liver disease and function assessment.

Main Methods:

  • Employed a 6-echo spoiled gradient-echo sequence with dual flip angles and undersampling.
  • Utilized multicontrast compressed-sensing reconstruction for accelerated data acquisition (18-second scan time).
  • Applied iterative least-squares for R2* and proton density fat fraction mapping, and driven equilibrium single-pulse observation of T1 for T1 mapping. Validated with phantom and volunteer studies.

Main Results:

  • Quantitative values obtained using the novel method showed excellent agreement with conventional MRI techniques.
  • T1 values for water protons in phantoms and volunteers correlated well with Magnetic Resonance Spectroscopy (MRS) measurements.
  • The approach demonstrated high accuracy and reproducibility for multiparameter mapping.

Conclusions:

  • A rapid, single breath-hold MRI technique enables accurate multiparameter quantitative mapping of T1, R2*, and proton density fat fraction.
  • This approach holds significant potential for efficient and comprehensive liver disease evaluation.
  • The method offers a promising tool for non-invasive assessment of liver function and disease.