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Development of New Therapeutic Applications Using Microfluidics
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CMOS Enabled Microfluidic Systems for Healthcare Based Applications.

Sherjeel M Khan1, Abdurrahman Gumus1,2, Joanna M Nassar1

  • 1Integrated Nanotechnology Lab and Integrated Disruptive Electronic Applications (IDEA) Lab, Computer Electrical Mathematical Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.

Advanced Materials (Deerfield Beach, Fla.)
|February 28, 2018
PubMed
Summary
This summary is machine-generated.

CMOS-enabled microfluidics integrate bioanalysis and data management for accessible, affordable personalized healthcare. This technology is crucial for expanding healthcare reach globally.

Keywords:
CMOSdrug deliveryhealthcareimage sensorlab on chipmicrofluidicspoint-of-care

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Semiconductor Technology

Background:

  • Growing global population necessitates accessible and affordable personalized healthcare solutions.
  • Integration of microfluidic systems with Complementary Metal-Oxide-Semiconductor (CMOS) technology is vital for advanced bioanalysis and drug delivery.
  • Current healthcare systems face challenges in delivering personalized medicine at scale.

Purpose of the Study:

  • To present the fundamentals, integration strategies, and applications of CMOS-enabled microfluidic systems for personalized healthcare.
  • To review critical components including sensors and actuators, along with their fabrication and packaging.
  • To highlight the potential of this integrated technology in the context of the Internet-of-Things and Internet-of-Everything.

Main Methods:

  • Review and discussion of fundamental principles of microfluidics and CMOS technology.
  • Detailed examination of component integration, fabrication, and packaging techniques.
  • Analysis of current and potential applications in personalized healthcare.

Main Results:

  • CMOS-enabled microfluidics offer a viable pathway for seamless bioanalysis and data management.
  • Key components like sensors and actuators are reviewed, detailing their fabrication and integration challenges.
  • The synergy between microfluidics and CMOS technology is demonstrated for healthcare applications.

Conclusions:

  • CMOS-enabled microfluidic systems are poised to significantly enhance affordable personalized healthcare.
  • The integration facilitates the development of sophisticated, data-driven healthcare solutions.
  • This technology has immense potential for widespread adoption, improving global health outcomes.