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Elevated circulating ghrelin in patients with COPD: A meta-analysis.

Xue Zhang¹, Ting Yang², Junli Wang³

¹1 Department of Rheumatology, Luoyang Orthopedic Hospital of Henan Province, Luoyang, Henan, People's Republic of China.

Chronic Respiratory Disease

|March 1, 2018

Summary

This summary is machine-generated.

Circulating ghrelin levels are significantly elevated in patients with chronic obstructive pulmonary disease (COPD). This elevation is particularly pronounced in underweight COPD individuals, suggesting ghrelin supplementation as a potential therapy.

Keywords:

COPD Chronic obstructive pulmonary disease ghrelin malnutrition meta-analysis

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Area of Science:

Endocrinology
Pulmonology
Metabolic Research

Background:

Ghrelin, the endogenous ligand for the growth hormone secretagogue receptor, plays a role in various physiological processes.
Previous studies have reported conflicting findings regarding ghrelin levels in patients with chronic obstructive pulmonary disease (COPD).

Purpose of the Study:

To conduct a meta-analysis to determine the overall circulating level of ghrelin in COPD patients compared to controls.
To investigate the association between ghrelin levels and body mass index in COPD patients.

Main Methods:

A systematic search of the Pubmed and Embase databases was performed to identify relevant case-control or cohort studies.
Data from nine studies, including 515 subjects, were pooled using a random-effects model to calculate the standardized mean difference (SMD) and 95% confidence interval (CI).

Main Results:

The meta-analysis revealed significantly enhanced circulating ghrelin levels in COPD patients compared to controls (SMD: 0.83, 95% CI: 0.04 to 1.62, p = 0.039).
Ghrelin levels were significantly higher in underweight COPD patients than in normal weight COPD patients (SMD: 1.52, 95% CI: 0.43 to 2.61, p = 0.006).
No significant difference in ghrelin levels was observed between normal weight COPD patients and controls (SMD: 0.64, 95% CI: -0.36 to 1.63, p = 0.210).

Conclusions:

Circulating ghrelin levels are significantly elevated in individuals with COPD.
The elevated ghrelin levels are particularly notable in underweight COPD patients.
Exogenous ghrelin supplementation may represent a potential therapeutic strategy for underweight COPD patients.