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Updated: Feb 13, 2026
08:37
Corneal Donor Tissue Preparation for Endothelial Keratoplasty
Published on: June 12, 2012
28.2K
Five Keratoplasties From One Donor Cornea.
Oganes G Oganesyan1, Vladimir V Neroev, Arthur A Grdikanyan
1Department of Cornea Surgery, Helmholtz Moscow Institute of Eye Diseases, Moscow, Russia.
Cornea
|March 1, 2018
Summary
This study shows that one donor cornea can be successfully transplanted to five patients on the same day using deep anterior lamellar keratoplasty (DALK) and quarter Descemet membrane endothelial keratoplasty (Q-DMEK). This technique is feasible and can help alleviate corneal tissue shortages.
Area of Science:
- Ophthalmology
- Transplantation Surgery
- Corneal Science
Background:
- Corneal transplantation is limited by donor tissue availability.
- Developing methods to maximize donor cornea utilization is crucial for addressing shortages.
- Lamellar keratoplasty techniques offer tissue-sparing alternatives.
Purpose of the Study:
- To assess the feasibility of using a single donor cornea for five patients on the same day.
- To evaluate the outcomes of combining deep anterior lamellar keratoplasty (DALK) and quarter Descemet membrane endothelial keratoplasty (Q-DMEK).
Main Methods:
- A single donor cornea was processed to obtain stromal tissue for DALK and four quarter grafts for Q-DMEK.
- Deep anterior lamellar keratoplasty (DALK) was performed on one patient with keratoconus.
- Four quarter Descemet membrane endothelial keratoplasty (Q-DMEK) grafts were transplanted to patients with Fuchs dystrophy.
Main Results:
- All surgical procedures were completed successfully in a single session without complications.
- Six months postoperatively, best-corrected visual acuity was 0.66 for DALK and 0.95 for Q-DMEK.
- All corneas remained clear with good endothelial cell density post-transplantation.
Conclusions:
- One donor cornea can be successfully utilized for five recipients through DALK and Q-DMEK.
- This approach is technically challenging but feasible, potentially reducing corneal tissue scarcity and costs.
- Careful patient selection is essential for this technique, and further research is warranted.
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