Related Experiment Video

Updated: Feb 13, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.8K

Prognosis of Severe Traumatic Brain Injury Outcomes in Children

Semen V Meshcheryakov1,2, Zhanna B Semenova3, Valery I Lukianov3

  • 1Children's Clinical and Research Institute of Emergency Surgery and Trauma, Moscow, Russia. msaemon@rambler.ru.

Acta Neurochirurgica. Supplement
|March 2, 2018
PubMed

Insights

Predicting outcomes for severe traumatic brain injury (TBI) in children is possible using a personalized prognostic model. Key factors include Glasgow Coma Scale (GCS) and Injury Severity Score (ISS), improving early prediction accuracy.

Area of Science:

  • Pediatric Neurology
  • Neurotraumatology
  • Clinical Prognostics

Background:

  • Severe traumatic brain injury (TBI) in children presents significant challenges in predicting patient outcomes.
  • Accurate prognostication is crucial for guiding clinical management and resource allocation.

Purpose of the Study:

  • To identify key prognostic factors influencing outcomes in pediatric severe TBI.
  • To develop and validate a predictive model for TBI outcomes in children.

Main Methods:

  • Included 169 pediatric severe TBI patients, assessing Glasgow Coma Scale (GCS), Injury Severity Score (ISS), CT findings (Marshall scale), and intracranial pressure (ICP).
  • Measured serum biomarkers S-100β protein and neuron-specific enolase (NSE) in subsets of patients.
  • Utilized discriminant function analysis to create a prognostic model, validated on a separate cohort of 118 patients.

Main Results:

  • Glasgow Coma Scale (GCS), pupil reactivity, Injury Severity Score (ISS), hypotension, and hypoxia were significant predictors of outcome.
  • Computed tomography (CT) findings and serum biomarkers (S-100β ≤ 0.25 μg/l, NSE < 19 μg/l) improved prognostic accuracy to 76%.
  • The validated mathematical prognostic model achieved an overall accuracy of 86%.

Conclusions:

  • A personalized prognostic model enables early prediction of severe TBI outcomes in children within the first day post-trauma.
  • This model aids in tailoring treatment strategies and managing expectations for pediatric TBI patients.
Abstract

Keywords:
Intracranial hypertensionMath modelOutcomesPrognosisSevere brain injury

More Related Videos

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury04:19

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

Published on: June 20, 2017

11.7K
Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice11:04

Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice

Published on: August 22, 2011

41.4K

Related Concept Videos

Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
11.0K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.8K
Traumatic Memory01:20

Traumatic Memory

Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
596
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
4.1K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
328
Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
593