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Is Eye Color Related to Dental Injection Pain? A Prospective, Randomized, Single-blind Study
Jason Hyde1, Sara Fowler2, Melissa Drum2
1Private Practice Limited to Endodontics, St Louis, Missouri.
Journal of Endodontics
|March 7, 2018
Summary
This study found no link between eye color and injection pain perception in white women. Therefore, eye color cannot predict dental treatment pain in this population.
Area of Science:
- Pain perception research
- Genetics and biomarkers
- Dental anesthesia studies
Background:
- Emerging research links pain perception to phenotypes like hair and eye color.
- Understanding pain biomarkers can illuminate genetic pathways.
- Clinical utility exists in predicting dental injection pain based on patient eye color.
Purpose of the Study:
- To investigate the association between eye color and perceived injection pain.
- To determine if eye color can predict pain during dental procedures.
- Focus on healthy, asymptomatic white women.
Main Methods:
- Included 300 healthy adult white women (133 dark-eyed, 167 light-eyed).
- Assessed dental anxiety using the Corah Dental Anxiety Scale.
- Administered lidocaine with epinephrine injection, with pain rated on a visual analog scale.
- Categorized eye color (dark/light) by independent observers.
Main Results:
- No statistically significant differences in injection pain were observed between dark-eyed and light-eyed subjects.
- Pain perception during dental injection did not correlate with eye color.
Conclusions:
- Eye color is not a reliable predictor of injection pain in white women.
- Clinical application of eye color for predicting dental pain is not supported by this study.
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