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[Cortical Midline Structures: "Self" and "Pain"].

Shigeyuki Kan1, Satoru Miyauchi

  • 1Department of Pain Medicine, Osaka University Graduate School of Medicine.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|March 10, 2018
PubMed
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Cortical midline structures (CMS) are crucial for self-representation and overlap with pain networks. Disruptions in CMS are linked to chronic pain and neurological disorders, offering insights into self-cognition and pain pathology.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Pain Research

Background:

  • Cortical midline structures (CMS) are vital for self-representation.
  • CMS regions overlap with the default mode network (DMN) and salience network (SN).
  • CMS also overlaps with pain-related brain regions, suggesting unique attributes of pain processing.

Purpose of the Study:

  • To explore the role of CMS in self-representation.
  • To investigate the overlap between CMS, DMN/SN, and pain networks.
  • To understand the implications of CMS dysfunction in chronic pain and related disorders.

Main Methods:

  • Review of emerging evidence on CMS function.
  • Analysis of neuroimaging studies on self-cognition and pain.
  • Examination of the relationship between CMS and neurological/psychiatric conditions.

Related Experiment Videos

Main Results:

  • CMS regions, including OMPFC, DMPFC, ACC, and pC/PCC, are critical for self-cognition.
  • Significant overlap exists between CMS, DMN/SN hubs, and the pain matrix.
  • Disturbances in CMS are associated with chronic pain, neurological, and psychiatric diseases.

Conclusions:

  • The overlap between self-representation and pain networks in CMS offers novel insights into chronic pain mechanisms.
  • Understanding CMS function is key to addressing the cognitive aspects of pain and self-representation in brain disorders.