Related Experiment Video
Updated: Feb 13, 2026
12:09
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
18.6K
Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment
Matthew J Brookes1, Madeleine J Groom2, Lucrezia Liuzzi1
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom.
Neuroimage
|March 11, 2018
Summary
Brain connectivity strengthens with age, with both stable and dynamic network patterns evolving from childhood to adulthood. This study used magnetoencephalography (MEG) to map these crucial neurodevelopmental changes.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Cognitive Neuroscience
Background:
- Human brain function relies heavily on network connectivity.
- Understanding the maturation of brain networks is key to identifying healthy and atypical neurodevelopment.
- Electrophysiological methods are crucial for studying brain network dynamics.
Purpose of the Study:
- To investigate the maturational trajectory of stationary and dynamic electrophysiological connectivity in the human brain.
- To examine age-related changes in functional connectivity using magnetoencephalography (MEG).
- To explore the relationship between dynamic network alterations and age-modulated functional connectivity.
Main Methods:
- Magnetoencephalography (MEG) was employed to assess electrophysiological connectivity.
- Analysis included both stationary (time-averaged) and dynamic (rapidly modulating) connectivity measures.
- Participants ranged from mid-childhood (9 years) to early adulthood (25 years).
Main Results:
- Stationary functional connectivity, particularly in alpha and beta bands, increased with age, especially in parietal and temporo-parietal regions.
- Dynamic analysis identified 8 distinct networks modulating on a ~100 ms timescale, with increasing temporal stability in attentional networks.
- Significant overlap was observed between age-modulated dynamic networks and inter-regional oscillatory coordination, suggesting dynamic alterations underlie connectivity changes.
Conclusions:
- Brain network electrophysiology undergoes significant changes from childhood to early adulthood.
- Age-related increases in stationary connectivity and temporal stability of dynamic networks are key findings.
- These insights provide a foundation for understanding neurodevelopmental disorders affecting brain connectivity.
Related Concept Videos
02:26Protein Networks
4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
01:30Alterations in Respiration II
1.9K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.9K
03:18Nuclear Stability
23.4K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
To hold positively charged protons together...
23.4K
01:53RNA Stability
35.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.8K
01:06Altered States of Awareness
1.2K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.2K