Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Histone Variants at the Centromere02:30

Histone Variants at the Centromere

5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
DNA Replication02:40

DNA Replication

60.3K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
60.3K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.9K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.9K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

8.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
8.2K
From DNA to Protein03:06

From DNA to Protein

22.6K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
22.6K
Recombinant DNA01:09

Recombinant DNA

103.5K
Overview
103.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Odorant Binding Causes Cytoskeletal Rearrangement, Leading to Detectable Changes in Endothelial and Epithelial Barrier Function and Micromotion.

Biosensors·2023
Same author

Eradication of avian leukosis virus subgroups J and K in broiler cross chickens by selection against infected birds using multilocus PCR.

PloS one·2022
Same author

Low Additive Genetic Variation in a Trait Under Selection in Domesticated Rice.

G3 (Bethesda, Md.)·2020
Same journal

Duplication-based genetic dissection of the Down syndrome critical region reveals its complex functional organization.

G3 (Bethesda, Md.)·2026
Same journal

The complete sequence of the silkworm W chromosome uncovers its rapid evolution by large-scale duplications/deletions and translocation of W-linked genes.

G3 (Bethesda, Md.)·2026
Same journal

Revisiting the genome assembly of Lupinus species reveals differential diploidization after a shared whole-genome duplication.

G3 (Bethesda, Md.)·2026
Same journal

Deconstructing empirical fitness seascapes across scales of granularity.

G3 (Bethesda, Md.)·2026
Same journal

Genomes of Conopholis americana and Epifagus virginiana: Two holoparasitic plants (Orobanchaceae).

G3 (Bethesda, Md.)·2026
Same journal

"A chromosome-level reference genome for the colonial marine hydrozoan Podocoryna americana".

G3 (Bethesda, Md.)·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.8K

Fast Ordered Sampling of DNA Sequence Variants.

Anthony J Greenberg1

  • 1Bayesic Research, Ithaca, NY 14850 tonyg@bayesicresearch.org.

G3 (Bethesda, Md.)
|March 14, 2018
PubMed
Summary
This summary is machine-generated.

Genomic data analysis is accelerated by a fast, memory-efficient sampling method. This technique enables quick estimation of genome-wide linkage disequilibrium (LD) patterns on modern hardware, making large datasets more accessible.

Keywords:
C++genomicsnucleotide polymorphismrandom samplingstatistical genetics

More Related Videos

Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

38.0K
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.8K

Related Experiment Videos

Last Updated: Feb 13, 2026

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.8K
Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

38.0K
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.8K

Area of Science:

  • Computational Biology
  • Genomics
  • Bioinformatics

Background:

  • The exponential growth of genomic data necessitates efficient computational methods.
  • Consumer-grade computers are becoming increasingly powerful, enabling local analysis of large datasets.
  • On-line sampling techniques offer a way to manage and analyze large files without requiring extensive computational resources.

Purpose of the Study:

  • To implement and evaluate a fast, memory-efficient on-line sampling method for genomic data on modern hardware.
  • To demonstrate the utility of this sampling method for estimating genome-wide patterns of linkage disequilibrium (LD) decay.
  • To provide open-source software tools for sampling variant files and estimating LD decay.

Main Methods:

  • Implementation of a 30-year-old on-line sampling algorithm optimized for modern storage (SSDs, HDDs).
  • Performance testing of the sampling method on genotype files using contemporary hardware.
  • Development of a method to estimate genome-wide LD decay patterns using the sampling technique.

Main Results:

  • The on-line sampling method performs efficiently on modern solid-state and spinning hard drives.
  • The technique is comparable in performance to simpler sampling schemes.
  • The method successfully enables rapid estimation of genome-wide LD decay with distance.

Conclusions:

  • The re-implemented on-line sampling method is a valuable tool for analyzing large genomic datasets on accessible hardware.
  • This approach facilitates rapid estimation of population genetics parameters like LD decay.
  • Open-source software is provided to support broader adoption in genomic research.