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Updated: Feb 13, 2026
08:42
A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
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Perioperative Complications Following Surgery for Necrotizing Enterocolitis
Annika Mutanen1, Agostino Pierro1, Augusto Zani1
1Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.
Summary
Necrotizing enterocolitis (NEC) surgery in premature infants often leads to severe complications. These surgical complications can negatively impact long-term gut and brain development.
Area of Science:
- Neonatalogy
- Pediatric Surgery
Background:
- Necrotizing enterocolitis (NEC) is a severe intestinal disease primarily affecting premature infants.
- Surgical intervention for advanced NEC is frequently required.
Purpose of the Study:
- To highlight the significant perioperative morbidity associated with NEC surgery.
- To underscore the potential long-term consequences of these complications on infant outcomes.
Main Methods:
- Review of existing literature on NEC surgical outcomes.
- Analysis of reported perioperative complications in NEC patients.
Main Results:
- Up to 70% of infants undergoing NEC surgery experience significant perioperative complications.
- Common complications include anastomosis/enterostomy issues, sepsis, peritonitis, and wound infections.
Conclusions:
- Perioperative complications are a major concern in NEC surgical management.
- These complications can adversely affect the long-term gastrointestinal and neurodevelopmental health of affected infants.
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