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Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

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The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Overview of Advanced Functional Groups02:22

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
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Testosterone: Functions and Regulation01:26

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Hormones of the Pituitary Gland01:27

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The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Related Experiment Video

Updated: Feb 13, 2026

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
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Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology

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Basic Research Advances on Pituitary Stem Cell Function and Regulation.

John P Russell, Emily J Lodge, Cynthia L Andoniadou

    Neuroendocrinology
    |March 15, 2018
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    Summary
    This summary is machine-generated.

    Pituitary stem cells are crucial for gland function but poorly understood. Research aims to uncover their regulation for treating pituitary disorders and advancing regenerative medicine.

    Keywords:
    HippoPituitary stem cellRegenerative medicineSOX2YAP/TAZ

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    Area of Science:

    • Endocrinology
    • Stem Cell Biology
    • Developmental Biology

    Background:

    • The pituitary gland is a central regulator of physiological processes.
    • Pituitary stem cells generate new cells during development but are quiescent in adulthood.
    • Regulation of pituitary stem cells is poorly understood, hindering treatment of pituitary disorders.

    Purpose of the Study:

    • To review current methodologies for studying pituitary stem cells.
    • To explore the normal regulation of pituitary stem cell populations.
    • To discuss future strategies for manipulating pituitary stem cells in disease and regenerative medicine.

    Main Methods:

    • Review of existing literature on pituitary stem cell research.
    • Analysis of methodologies used to characterize stem cell attributes.
    • Discussion of signaling mechanisms influencing stem cell proliferation and fate.

    Main Results:

    • Pituitary stem cells are dynamic and responsive to physiological demands.
    • Current understanding of pituitary stem cell regulation is limited.
    • Potential therapeutic targets for pituitary disorders are being identified.

    Conclusions:

    • A deeper understanding of pituitary stem cell regulation is essential.
    • Future research should focus on signaling pathways for therapeutic manipulation.
    • Advances in pituitary stem cell research hold promise for regenerative medicine and disease treatment.