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Superparamagnetic lipid-based hybrid nanosystems for drug delivery
E Millart1, S Lesieur1, V Faivre1
1a Institut Galien Paris-Sud , CNRS, Univ. Paris-Sud, Université Paris-Saclay , Châtenay-Malabry , France.
Expert Opinion on Drug Delivery
|March 16, 2018
Summary
This review explores biocompatible lipid-based nanotechnologies for co-encapsulating drugs and superparamagnetic iron oxide nanoparticles. These hybrid systems offer combined chemotherapy with potential for targeted delivery, controlled release, and hyperthermia treatment.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Multifunctional drug carriers enable advanced therapeutic strategies.
- Superparamagnetic iron oxide nanoparticles (SPIONs) combined with drugs offer dual-action capabilities.
- Lipid-based nanotechnologies are explored for co-encapsulating therapeutic agents and SPIONs.
Purpose of the Study:
- To review biocompatible lipid-based nanotechnologies for co-encapsulating drugs and iron oxide.
- To describe the preparation and rationale behind these hybrid nano-objects.
- To discuss challenges in achieving uniform drug-to-iron oxide ratios in multifunctional carriers.
Main Methods:
- Literature review of lipid-based nanotechnologies for co-encapsulation.
- Analysis of lipid properties in forming nano-architectures (monophasic vs. complex).
- Discussion of preparation strategies for hybrid drug-SPION nanocarriers.
Main Results:
- Lipids can form diverse nanostructures suitable for co-encapsulation.
- Hybrid systems integrate chemotherapy with SPIONs for enhanced functionalities.
- Challenges exist in controlling the drug-to-iron oxide ratio within these carriers.
Conclusions:
- Biocompatible lipid nanocarriers show promise for multifunctional drug delivery.
- Co-encapsulation of drugs and SPIONs enables combined therapies and theranostics.
- Further research is needed to overcome challenges in constructing these complex nanocarriers.
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