Related Experiment Video
Updated: Feb 13, 2026
09:12
Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics
Published on: May 28, 2016
11.7K
Extreme sensitive metasensor for targeted biomarkers identification using colloidal nanoparticles-integrated
Arash Ahmadivand1, Burak Gerislioglu1, Asahi Tomitaka2
1Department of Electrical and Computer Engineering, Florida International University, 10555 W Flagler St., Miami, FL 33174, USA.
Biomedical Optics Express
|March 20, 2018
Summary
This study presents a novel terahertz (THz) metasensor using toroidal metamaterials for rapid biomarker detection. Integrating gold nanoparticles significantly enhances sensitivity for early infection diagnosis and pharmacology.
Area of Science:
- Terahertz (THz) spectroscopy
- Plasmonic metamaterials
- Biosensing applications
Background:
- Terahertz (THz) metamaterials offer non-destructive analysis of biological tissues.
- Toroidal metamaterials exhibit sharp resonance modes suitable for sensing.
- Existing THz sensors require further sensitivity improvements for low-concentration analytes.
Purpose of the Study:
- To develop a THz metasensor utilizing toroidal metamolecules for ultra-low concentration biomarker detection.
- To enhance sensor performance through the integration of gold nanoparticles (GNPs).
- To evaluate the sensitivity, repeatability, and limit of detection (LoD) of the proposed sensor.
Main Methods:
- Design and numerical optimization of a toroidal plasmonic metasurface.
- Fabrication using standard microfabrication techniques.
- Functionalization with antibodies for selective biomarker (ZIKV-EPs) capture.
- Quantification via spectral shifts of toroidal resonances.
- Comparative analysis with and without GNP integration.
Main Results:
- The metasensor successfully detected and quantified target biomarker proteins (ZIKV-EPs).
- Integration of GNPs decorated with antibodies enhanced biomarker capture and sensor sensitivity.
- A 100-fold sensitivity enhancement was achieved compared to devices without GNPs.
- The sensor demonstrated capability for detecting low molecular-weight biomolecules (≈13 kDa) in diluted solutions.
Conclusions:
- Toroidal THz metasensors offer a promising platform for sensitive and specific biomolecule detection.
- The integration of plasmonic nanoparticles significantly boosts sensor performance.
- This technology has potential applications in rapid infection diagnosis and real-time pharmacology.
Related Concept Videos
03:22Colloids
21.3K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
21.3K
01:29Pharmacogenomics: Identification of New Drug Targets
2
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
2
01:17Colloids and Suspensions
3.5K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
3.5K
01:09Colloidal precipitates
6.5K
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
6.5K
03:38Measurement: Standard Units
82.2K
Every measurement provides three kinds of information: the size or magnitude of the measurement (a number), a standard of comparison for the measurement (a unit), and an indication of the uncertainty of the measurement. While the number and unit are explicitly represented when a quantity is written, the uncertainty is an aspect of the errors in the measurement results.
82.2K
03:02Measurement: Derived Units
56.0K
The International System of Units or SI system, by international agreement, has fixed measurement units for seven fundamental properties: length, mass, time, temperature, electric current, amount of substance, and luminosity. These are called the SI base units.
56.0K