Related Experiment Video
Updated: Feb 13, 2026
05:05
Ultrasound Cyclo Plasty in Eyes with Glaucoma
Published on: January 26, 2018
12.7K
Glaucoma With Crouzon Syndrome
Abdulaziz A Alshamrani1, Sami Al-Shahwan
1King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Journal of Glaucoma
|March 21, 2018
Summary
Crouzon syndrome can cause shallow anterior chambers and closed angles, leading to congenital glaucoma. This is linked to fibroblast growth factor receptor 2 (FGFR2) gene mutations affecting anterior segment development.
Area of Science:
- Ophthalmology
- Genetics
- Pediatrics
Background:
- Crouzon syndrome, a common craniosynostosis, is linked to fibroblast growth factor receptor 2 (FGFR2) and 3 (FGFR3) gene mutations.
- Understanding the genetic basis of Crouzon syndrome is crucial for managing associated ocular conditions.
Observation:
- A 10-year-old female with Crouzon syndrome presented with congenital glaucoma, proptosis, and megalocornea.
- Ocular examination revealed thin corneas, shallow anterior chambers, and a high cup-to-disc ratio.
- Ultrasound biomicroscopy showed closed angles in the right eye and narrow angles in the left eye, despite long axial lengths.
Findings:
- Shallow anterior chambers and occluded angles can occur in Crouzon syndrome, even with long axial lengths.
- This anterior segment dysgenesis is likely due to FGFR2 gene mutations.
- This case highlights a secondary cause of congenital glaucoma in Crouzon syndrome.
Implications:
- Recognizing anterior segment dysgenesis is vital for managing glaucoma in Crouzon syndrome patients.
- Genetic factors in Crouzon syndrome can significantly impact ocular structures and predispose to glaucoma.
- Further research into FGFR2-related ocular manifestations is warranted.
Related Concept Videos
01:25Glaucoma: Overview
1.4K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.4K
01:27Open Angle Glaucoma: Treatment
1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
01:28Angle Closure Glaucoma: Treatment
1.3K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.3K
01:24Nephrotic Syndrome I : Introduction
689
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
689
01:30Acute Coronary Syndrome I: Introduction
1.1K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.1K
01:17Irritable Bowel Syndrome I: Introduction
1.1K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.1K