DEVELOPMENT OF THE FORMULATION AND TECHNOLOGY OF HYDROGEL, CONTAINING ADJARA REGION SULFIDE SILT PELOID

In the world today, the demand for the preparations and cosmetics, made of peloids is increasing significantly, which is explained by the increased interest of the community to the ecologically clean raw materials of natural origin, it often replaces expensive chemical preparations, which are often accompanied by some contraindications. The increased interest in peloids in the world put on the agenda the question of rational use of acting mud mines as well as the problem of cosmetic and medicinal preparations, developed on their basis. It is noteworthy that the development of ready-made, soft drug forms from the Adjara region sulfide silt peloids is one of the most topical and important issues, as at present there is not available the form of ready-made drugs containing the sulfide silt peloids of this region. Therefore, the aim of the research was to develop the formulation and technology of the hydrogel, containing the Adjara region sulfide silt peloid. The sulfide silt peloid of the Ardagani lake have been used for preparing the hydrogel compositions, as it is distinguished by its advantageous physical-chemical properties and content of biologically active ingredients compared with other studied peloids. The main physical-chemical and technological characteristics of hydrogels compositions have been studied using the following methods: uniformity, pH, the colloidal stability, thermal stability , osmotic activity - by dialysis method using semiconductor membrane (Kruvichinski method), release of active ingredient was studied by using Franz diffusion cells, viscosity was determined by Viscometer RVDV-1 T (Dongguan Zhongli Instrument Technology Co., China), the structure of hydrogel composition - by microscopic (ROW Rathenow, Germany) examination. Based on the conducted studies have been established, that the hydrogel composition N6 is distinguished by its best properties compared to other hydrogel compositions, in which the carboxymethylcellulose was used as a base.The conducted studies became the basis for the development of the formula and technological scheme of production for the hydrogel of Ardagani lake sulfide silt peloid of Adjara region. The results of determining the main characteristics of the given gel provide the desired quality and efficiency of the product.