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Development of Novel Octanoyl Chitosan Nanoparticles for Improved Rifampicin Pulmonary Delivery: Optimization by
Kailash C Petkar1,2, Sandip Chavhan1, N Kunda3
1Faculty of Pharmacy, Department Pharmaceutics, The Maharaja Sayajirao University of Baroda, Vadodara, 390001, Gujarat, India.
AAPS Pharmscitech
|March 29, 2018
Summary
Octanoyl chitosan nanoparticles were developed for pulmonary drug delivery. These novel nanoparticles effectively encapsulated rifampicin, showing sustained release and good aerosolization properties for potential lung treatments.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Pulmonary drug delivery offers targeted treatment for lung diseases.
- Chitosan derivatives are explored for drug encapsulation due to their biocompatibility.
- Developing stable nanoparticles with suitable aerosolization properties is crucial for effective lung delivery.
Purpose of the Study:
- To synthesize and characterize a novel hydrophobic chitosan derivative, octanoyl chitosan (OC).
- To prepare and optimize rifampicin-loaded OC nanoparticles for pulmonary delivery.
- To evaluate the physicochemical properties, aerosolization, and in vitro drug release of the developed nanoparticles.
Main Methods:
- Octanoyl chitosan (OC) was synthesized and characterized.
- Nanoparticles were prepared using the double emulsion solvent evaporation technique.
- Particle size, morphology, entrapment efficiency, cytotoxicity, aerosol performance, and in vitro release were evaluated.
- A 3^2 full factorial design was employed for optimization.
Main Results:
- Successfully synthesized OC with improved organic solubility and no significant cytotoxicity.
- Optimized OC nanoparticles exhibited spherical morphology, a mean size of 253 nm, and 64.86% rifampicin entrapment efficiency.
- The nanoparticles demonstrated a fine particle fraction of 43.27% and sustained rifampicin release over 72 hours.
- Physical stability was maintained for up to 2 months.
Conclusions:
- Octanoyl chitosan is a suitable material for developing nanoparticle formulations for pulmonary drug delivery.
- The developed OC nanoparticles possess favorable characteristics for aerosolization and sustained drug release.
- These findings support the potential of OC nanoparticles for targeted lung therapies.
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