Related Experiment Video

Updated: Feb 12, 2026

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
08:38

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Published on: August 26, 2017

7.6K

Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease

Fumihiro Sanada1, Yoshiaki Taniyama2, Jun Muratsu3,4

  • 1Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan. sanada@cgt.med.osaka-u.ac.jp.

Medicines (Basel, Switzerland)
|March 31, 2018
PubMed

Insights

Therapeutic angiogenesis shows promise for treating peripheral artery disease (PAD), a common cause of death. This review explores growth factor therapies for PAD to improve vascularization and reduce ischemic complications.

Area of Science:

  • Cardiovascular Research
  • Regenerative Medicine
  • Vascular Biology

Background:

  • Cardiovascular diseases, including coronary artery disease (CAD) and peripheral artery disease (PAD), are leading causes of global mortality.
  • Atherosclerosis, characterized by lipid deposition and arterial narrowing, underlies CAD and PAD, leading to significant morbidity and mortality despite current interventions.
  • Existing treatments for CAD and PAD, such as percutaneous transluminal angioplasty, have limitations, highlighting the need for novel therapeutic strategies.

Purpose of the Study:

  • To review the current state of therapeutic angiogenesis using angiogenic growth factors for peripheral artery disease (PAD).
  • To discuss basic and clinical data from studies investigating angiogenic therapies for PAD.
  • To evaluate the biological processes involved in new vascularization for PAD treatment.

Main Methods:

  • Review of existing literature on therapeutic angiogenesis and angiogenic growth factors in PAD.
  • Analysis of basic science data related to vascularization mechanisms.
  • Examination of clinical trial outcomes for angiogenic therapies in PAD patients.

Main Results:

  • Therapeutic angiogenesis using angiogenic growth factors has been investigated for nearly two decades for ischemic heart and limb diseases.
  • Evidence suggests both successful and unsuccessful outcomes in gene therapy approaches for PAD.
  • The efficacy and mechanisms of angiogenic growth factors in promoting new blood vessel formation in PAD require further elucidation.

Conclusions:

  • New therapeutic strategies, particularly therapeutic angiogenesis, are crucial for addressing the unmet needs in PAD treatment.
  • Angiogenic growth factor-based therapies offer a potential avenue for stimulating new vasculature to improve blood flow in ischemic tissues.
  • Further research into the biological processes and clinical application of therapeutic angiogenesis is essential for advancing PAD treatment options.

Keywords:
angiogenesisgene therapyhepatocyte growth factor

More Related Videos

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia07:48

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia

Published on: June 8, 2019

9.3K
Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles09:01

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

11.6K

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
393
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
395
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
368
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
425
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
458
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.2K