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Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer
Ying Liu1, Jian Cui2, Yun-Liang Tang3
1Department of Internal Medicine, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Biomed Research International
|April 3, 2018
Summary
The S100 protein family
Area of Science:
- Oncology
- Molecular Biology
Background:
- S100 proteins are implicated in cancer cell invasion and metastasis.
- The prognostic significance of S100 protein expression in non-small-cell lung cancer (NSCLC) remains unclear.
Purpose of the Study:
- To investigate the prognostic role of individual S100 mRNA expression in NSCLC patients.
- To assess the association of S100 expression with overall survival (OS) across different NSCLC subtypes and clinical parameters.
Main Methods:
- Utilized the Kaplan-Meier plotter (KM plotter) database for analysis.
- Examined mRNA expression levels of S100 family members in relation to patient survival data.
Main Results:
- Expression of 14 S100 members correlated with OS in all NSCLC patients.
- Eighteen S100 members were associated with OS in adenocarcinoma, but none in squamous cell carcinoma.
- High S100B mRNA expression was linked to better OS in NSCLC patients.
Conclusions:
- S100 proteins exhibit significant prognostic value in NSCLC, particularly in adenocarcinoma.
- S100B may serve as a potential biomarker for improved survival in NSCLC.
- Findings suggest S100 proteins as therapeutic targets for NSCLC treatment, warranting further clinical validation.
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