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Generation of sulfonated 1-isoindolinones through a multicomponent reaction with the insertion of sulfur dioxide
Jun Zhang1, Feng Zhang, Lifang Lai
1Department of Chemistry, Fudan University (Jiangwan Campus), 2005 Songhu Road, Shanghai 200438, China. jie_wu@fudan.edu.cn.
Abstract:
A four-component reaction of 2-vinylbenzoic acids, aryldiazonium tetrafluoroborates, the sulfur dioxide surrogate DABCO·(SO2)2, and nitriles under photocatalysis in the presence of visible light is developed. This multicomponent reaction works efficiently, promoted by BF3·OEt2 with the insertion of sulfur dioxide under mild conditions, leading to sulfonated 1-isoindolinones in moderate to good yields. This route is highly selective, and several competitive pathways are not observed under these conditions. A possible mechanism involving photocatalysis and a Lewis acid is proposed.
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