Related Experiment Video
Updated: Feb 12, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.5K
The Evolving Landscape of Psoriasis Treatment
April W Armstrong1, Kenneth B Gordon2, M Alan Menter3
1Associate Professor of Clinical Dermatology Associate Dean for Clinical Research Keck School of Medicine of the University of Southern California Los Angeles, California.
Seminars in Cutaneous Medicine and Surgery
|April 4, 2018
Summary
New biologic drugs for plaque psoriasis highlight its systemic nature. Treatments range from topicals for mild cases to combination therapies for severe disease, achieving high Psoriasis Area and Severity Index (PASI) scores.
Area of Science:
- Dermatology and immunology, focusing on psoriatic disease mechanisms and therapeutic interventions.
Background:
- Plaque psoriasis is a complex, multisystemic inflammatory condition.
- Understanding its nature has driven the development of advanced therapeutic agents.
Observation:
- Current and emerging biologic agents demonstrate high efficacy in treating plaque psoriasis.
- Psoriasis Area and Severity Index (PASI) 75 is a key metric, with some treatments achieving up to 90% improvement.
Findings:
- Therapeutic selection is guided by disease severity, from topical agents for mild cases to systemic therapies for moderate-to-severe disease.
- Combination therapies, including oral agents, biologics, and phototherapy, are often necessary for effective symptom management.
Implications:
- Biologic therapies offer significant improvements in managing plaque psoriasis.
- Personalized treatment strategies combining multiple modalities are crucial for achieving rapid and comprehensive symptom relief in patients with moderate to severe psoriasis.
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