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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Essential Minerals for Bone Health01:31

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Water and Mineral Acquisition02:34

Water and Mineral Acquisition

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Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.
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Minerals01:26

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Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
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Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Progress and Problems in Bone and Mineral Disorders.

Neil Gittoes1

  • 1Centre for Endocrinology, Diabetes and Metabolism, Queen Elizabeth Hospital, University Hospitals Birmingham and University of Birmingham, UK.

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PubMed
Summary
This summary is machine-generated.

New osteoporosis drugs show promise, yet a treatment gap persists due to management uncertainties. Developments also target rare bone and calcium diseases.

Keywords:
OsteoporosisX-linked hypophosphatemiaXLHabaloparatidehypophosphatasiarososozumab

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Area of Science:

  • Bone biology and metabolic disorders.
  • Pharmacology and drug development.
  • Clinical management of bone diseases.

Background:

  • The osteoporosis therapy pipeline features promising new drugs, with some advancing while others fail.
  • Current osteoporosis management faces uncertainties, contributing to a significant 'treatment gap'.
  • Simultaneously, advancements are occurring in therapies for rare bone and calcium disorders.

Discussion:

  • The 'treatment gap' highlights a disparity between patients who could benefit from osteoporosis treatment and those actually receiving it.
  • Uncertainties in managing osteoporosis with existing medications exacerbate this gap.
  • Therapeutic progress is being made in both common osteoporosis and rarer bone/calcium diseases.

Key Insights:

  • Several novel osteoporosis therapies are progressing, indicating potential improvements in patient care.
  • A notable 'treatment gap' exists in osteoporosis management, underscoring unmet clinical needs.
  • Significant therapeutic developments are also emerging for rare bone and calcium diseases.

Outlook:

  • Continued research and development are crucial to bridge the osteoporosis treatment gap.
  • Addressing management uncertainties will be key to improving patient outcomes.
  • The parallel progress in rare bone disease therapies offers hope for specialized patient populations.