PELLETS AND PELLETIZATION: EMERGING TRENDS IN THE PHARMA INDUSTRY.

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems

Background:

• The field of drug delivery is rapidly advancing with novel particulate systems.
• Pelletization is a key technique for modified drug release, enhancing efficacy for challenging drugs.

Purpose of the Study:

• To review pelletization as a drug delivery technique.
• To discuss pellet characterization, fabrication methods, and suitable polymers.

Main Methods:

• Literature review of research articles, review articles, and books.
• Analysis of various pelletization techniques including extrusion-spheronization and layering.
• Evaluation of natural, semi-synthetic, and synthetic polymers for pellet formulation.

Main Results:

• Pelletization offers advantages like site-specific delivery, improved bioavailability, and taste masking.
• Various fabrication methods exist, including extrusion-spheronization, layering, and direct compression.
• A wide range of polymers can be utilized in pellet formulations.

Conclusions:

• Pelletization is a versatile and effective drug delivery strategy.
• The choice of fabrication technique and polymer is crucial for successful pellet formulation.
• Further research into novel pelletization approaches can optimize drug delivery.