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Updated: Feb 12, 2026

Assessing Specificity of Anticancer Drugs In Vitro
Published on: March 23, 2016
IN SILICO ADME STUDIES OF POLYAMINE CONJUGATES AS POTENTIAL ANTICANCER DRUGS
Abstract:
The ADME properties and drug-likeness of several polyamine derivatives containing dimeric phthalimide, quinoline, cinnoline and chromone moieties with three different polyamines: 1,4-bis(3-aninopropyl)piperazine, 4,9-dioxa-1,12-dodecanediamine and 3,3-diamino-N-methyldipropylamine as linkers were presented. These compounds are structurally related to DNA bisintercalators, a group of agents with anti-cancer activity. Their biological properties were previously assessed in vitio in a highly aggressive melanoma cell line A375. Current studies evaluate their potential to be qualified as drugs by performing in silico ADME screening. The research is carried out using Discovery Studio 3.0 ADMET protocol obtained from Accelrys and might be useful for further developing and optimization of potential anticancer drugs.
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