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Levodopa-Responsive Early-Onset Parkinsonism in Down Syndrome
Padmini Palat1, Francis Hickey1, Lina Patel1
1Children's Hospital Colorado, 13123 E. 16th Ave., Aurora, CO 80045, USA.
Case Reports in Neurological Medicine
|April 19, 2018
Summary
Individuals with Down syndrome (DS) may experience parkinsonism, a condition rarely reported in this population. Early diagnosis and treatment with carbidopa-levodopa can significantly improve their quality of life.
Area of Science:
- Neurology
- Genetics
- Gerontology
Background:
- Down syndrome (DS) is associated with an increased risk of Alzheimer's disease, typically manifesting in adulthood.
- Parkinsonism is infrequently documented in individuals with Down syndrome.
Observation:
- A case study of a 20-year-old woman with Down syndrome presenting with parkinsonism is detailed.
- The patient exhibited a significant positive response to carbidopa-levodopa treatment.
Findings:
- This case suggests that parkinsonism may be underreported in the Down syndrome population.
- The dramatic response to carbidopa-levodopa indicates a potential treatable neurological comorbidity.
Implications:
- Increased awareness and screening for parkinsonism in individuals with DS are warranted.
- Timely diagnosis and intervention can potentially enhance the quality of life for those with Down syndrome experiencing parkinsonism.
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