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Updated: Feb 11, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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TGF-β Inhibition and Immunotherapy: Checkmate

Karuna Ganesh1, Joan Massagué2

  • 1Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Department of Medicine, Memorial Hospital, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Immunity
|April 19, 2018
PubMed
Summary

Stromal TGF-β signaling causes immune exclusion, hindering cancer immunotherapy. Combining TGF-β inhibition with immunotherapy overcomes resistance, leading to complete responses in preclinical models.

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