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Phytotherapeutics in cancer invasion and metastasis

Bahare Salehi1, Paolo Zucca2, Mehdi Sharifi-Rad3

  • 1Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Phytotherapy Research : PTR
|April 20, 2018
PubMed

Insights

Natural compounds from plants offer a promising strategy to combat complex cancer biology. This review highlights phytochemicals with antiangiogenic and antimetastatic potential as adjuncts to conventional cancer therapies.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Cancer is a complex, multifactorial disease requiring multitarget therapeutic strategies.
  • The plant kingdom is a rich source of bioactive compounds with anticancer potential.
  • Conventional therapies can be enhanced by targeting multiple signaling pathways involved in cancer progression, such as angiogenesis and metastasis.

Purpose of the Study:

  • To provide an updated overview of bioactive phytochemicals.
  • To highlight their potential as adjuvants in conventional anticancer therapies.
  • To focus on compounds with antiangiogenic and antimetastatic activities.

Main Methods:

  • This study is a narrative review.
  • Literature search was conducted on bioactive phytochemicals.
  • Emphasis was placed on antiangiogenic and antimetastatic properties.

Main Results:

  • Numerous phytochemicals demonstrate significant antiangiogenic and antimetastatic effects.
  • These compounds can synergistically target multiple pathways crucial for carcinogenesis.
  • Phytochemicals show promise as complementary agents in cancer treatment.

Conclusions:

  • Bioactive phytochemicals represent a valuable resource for anticancer drug discovery.
  • Their multitargeting capabilities make them ideal adjuvants for conventional therapies.
  • Further research into phytotherapeutics can lead to novel strategies against cancer metastasis and angiogenesis.
Keywords:
adjuvant therapyanticancer drugscancer chemopreventionchemotherapyphytochemicalsplant products

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