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Donated chemical probes for open science.
Susanne Müller1, Suzanne Ackloo2, Cheryl H Arrowsmith3
1Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany.
Elife
|April 21, 2018
Summary
Pharmaceutical companies created a collaboration to share high-quality chemical probes and data. This initiative provides researchers with essential tools and guidance for selecting chemical probes, advancing scientific discovery.
Area of Science:
- Biochemistry and Chemical Biology
- Drug Discovery and Development
Background:
- Small molecule modulators, or chemical probes, are vital research reagents for studying protein function.
- The pharmaceutical industry possesses numerous high-quality chemical probes, but associated data and control compounds are often inaccessible to academia.
- Limited access to probe data and guidance hinders researchers in selecting appropriate chemical tools.
Purpose of the Study:
- To describe a pre-competitive collaboration among pharmaceutical companies to make innovative chemical probes and associated data publicly available.
- To provide researchers with access to high-quality chemical probes, control compounds, and usage recommendations.
- To encourage broader participation in the Open Science Probes project.
Main Methods:
- Formation of a pre-competitive collaboration involving multiple pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, Takeda).
- Compilation and dissemination of a large collection of high-quality chemical probes.
- Inclusion of all probe-associated data, inactive control compounds, and usage recommendations.
Main Results:
- A significant number of innovative, well-characterized chemical probes have been made available through the Open Science Probes initiative.
- Comprehensive data, including control compounds and usage guidance, accompanies each chemical probe.
- A dedicated online platform (
- uri
- xlink:href=
- https://openscienceprobes.sgc-frankfurt.de
- >https://openscienceprobes.sgc-frankfurt.de
Conclusions:
- The Open Science Probes collaboration enhances accessibility of critical chemical biology tools for academic research.
- This initiative aims to empower researchers by providing reliable data and well-characterized probes, facilitating informed tool selection.
- The project encourages further contributions to expand the collective knowledge base of chemical probes and their applications.
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