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Mirtazapine.

Abdulrahman Al-Majed1, Ahmed H Bakheit2, Raed M Alharbi1

  • 1College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology
|April 22, 2018
PubMed
Summary
This summary is machine-generated.

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Mirtazapine, a noradrenergic and specific serotonergic antidepressant (NaSSA), effectively treats depression and other conditions. This profile details its pharmacology, pharmacokinetics, and physicochemical properties, supported by extensive references.

Area of Science:

  • Pharmacology
  • Medicinal Chemistry

Background:

  • Mirtazapine is an antidepressant medication.
  • It is also used for anxiety, insomnia, nausea, and weight gain.
  • It acts as an antagonist to adrenergic and serotonin receptors and has antihistamine properties.

Purpose of the Study:

  • To provide a comprehensive profile of mirtazapine.
  • To detail its nomenclature, synthesis, and properties.
  • To summarize its pharmacological and pharmacokinetic data.

Main Methods:

  • Literature review and data compilation.
  • Analysis of physicochemical properties (pKa, solubility, melting point, X-ray diffraction).
  • Summary of analytical methods (compendial, electrochemical, spectroscopic, chromatographic).
Keywords:
Clinical pharmacokineticsMethod of analysisMirtazapineNomenclaturePharmacological profilePhysical characteristicsSpectroscopyStabilitySynthesis

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Main Results:

  • Detailed information on mirtazapine's chemical and physical characteristics.
  • Overview of synthesis methods and analytical techniques.
  • Summary of absorption, distribution, metabolism, and elimination (ADME) profiles.

Conclusions:

  • Mirtazapine is a versatile antidepressant with a well-defined profile.
  • The profile consolidates essential data for researchers and clinicians.
  • Approximately 100 references support the compiled information.