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Grinspan's Syndrome: A Rare Case with Malignant Transformation
Numan Kökten1, Lokman Uzun1, Ayşe Serap Karadağ2
1Department of Otolaryngology, Istanbul Medeniyet University Medical Faculty, Goztepe Training and Research Hospital, Istanbul, Turkey.
Case Reports in Otolaryngology
|April 25, 2018
Summary
Oral lichen planus, a precancerous condition, can transform into oral cancer. This case highlights Grinspan's syndrome, emphasizing the need for vigilant monitoring of oral lichen planus patients for early malignant changes.
Area of Science:
- Oral Medicine
- Oncology
- Dermatology
Background:
- Oral lichen planus (OLP) is a chronic inflammatory condition affecting oral mucosa.
- Grinspan's syndrome, described in 1966, associates OLP with diabetes mellitus and vascular hypertension.
- OLP is recognized as a precancerous lesion, necessitating careful monitoring.
Observation:
- A 60-year-old male with a 10-year history of OLP presented with a painless mass in the buccal mucosa.
- Clinical examination revealed bilateral OLP lesions and an exophytic tumor on the left buccal mucosa.
- Histopathology confirmed OLP and invasive oral squamous cell carcinoma arising in a pre-existing OLP area.
Findings:
- The case demonstrates malignant transformation of OLP within the context of Grinspan's syndrome.
- Surgical excision of the oral squamous cell carcinoma was performed.
- The resulting tissue defect was successfully reconstructed using a split-thickness skin graft.
Implications:
- Patients with OLP require long-term, close follow-up for early detection of malignant transformation.
- Prompt diagnosis and management are crucial for improving outcomes in OLP-associated malignancies.
- This case underscores the importance of recognizing Grinspan's syndrome and its potential for malignant progression.