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Sacubitril/Valsartan: From Clinical Trials to Real-world Experience

Joanna M Joly1, Akshay S Desai2

  • 1Cardiovascular Division, Brigham & Women's Hospital, 75 Francis St., Boston, MA, 02115, USA.

Current Treatment Options in Cardiovascular Medicine
|April 25, 2018
PubMed

Insights

Sacubitril/valsartan significantly reduces cardiovascular death and heart failure progression in patients with heart failure with reduced ejection fraction (HFrEF). Real-world data confirm its safety and efficacy, supporting guideline updates.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Heart failure with reduced ejection fraction (HFrEF) remains a significant cause of morbidity and mortality.
  • Angiotensin-receptor neprilysin inhibitors represent a novel therapeutic class for HFrEF management.

Purpose of the Study:

  • To review the real-world clinical experience with sacubitril/valsartan in HFrEF patients.
  • To discuss the evidence supporting guideline updates favoring sacubitril/valsartan over ACE inhibitors or ARBs.

Main Methods:

  • Review of clinical trials and real-world data on sacubitril/valsartan.
  • Analysis of updated clinical practice guidelines.

Main Results:

  • Sacubitril/valsartan demonstrates substantial reductions in cardiovascular mortality and HFrEF progression compared to enalapril.
  • A growing body of evidence supports the safety and efficacy of sacubitril/valsartan across diverse HFrEF patient populations.

Conclusions:

  • Sacubitril/valsartan is recommended in updated guidelines for selected HFrEF patients.
  • Practical strategies for patient selection and utilization are discussed.
  • Areas requiring future research are identified.
Abstract

Keywords:
ARNIEnalaprilHFrEFPARADIGM-HFSacubitril/valsartan

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