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Updated: Feb 11, 2026

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
Published on: October 20, 2023
[Aortic stenosis is a common disease which requires individualized treatment]
Vendela Berglund1, Gustav Mattsson2, Peter Magnusson3
1Centrum för forskning och utveckling, Uppsala Universitet/Region Gävleborg - Gävle, Sweden Centrum för forskning och utveckling, Uppsala Universitet/Region Gävleborg - Gävle, Sweden.
Abstract:
Aortic stenosis is the most common valvular heart disease and the prevalence increases with age. Common symptoms include dyspnea, angina, and syncope. Echocardiography is a cornerstone in diagnosis of aortic stenosis. Severe aortic stenosis is defined as peak aortic jet velocity ≥4 m/s, a mean transvalvular gradient ≥40 mmHg, and/or an aortic valve area <1.0 cm2. The two-year mortality in patients with symptomatic aortic stenosis is 50 percent without intervention. The only efficient treatment is intervention, either open heart valve replacement or percutaneous transcatheter implantation of an aortic valve prosthesis (TAVI), which both provide symptomatic relief and improved survival. Many patients with aortic stenosis are elderly with comorbidities, thus making treatment decision challenging and requiring individual judgement.
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