[Antitumor effectiveness of chalone-like proteoglycans isolated from normal and tumor tissues]

Chalone-like proteoglycans (PG) have been isolated from 22a hepatoma, spontaneous adenocarcinoma of the mammary gland of C3H/He mice and from transplanted X-ray-induced lymphoma in C57Bl mice. It has been found that the biological activity of these PG was considerably weaker than that of PG taken from the liver, mammary gland and spleen of cattle. PG from 22a hepatoma produced a weaker tissue-specific antimitotic effect as against PG from the liver when acting on the liver cells of 6-day C57Bl mice, while the lymphoma PG under these conditions was ineffective. PG from the liver and mammary gland inhibited the growth of certain transplanted tumours in vitro. The lymphoma PG has stimulated the tumour growth.