Effects of Lower Limb Cycle Training on Echocardiographic Parameters of Left Ventricle in Dilated Cardiomyopathy

Mehwish Waseem1, Naveed Yaqoob2, Muhammad Iqbal Tariq1

  • 1Riphah College of Rehabilitation Sciences, Riphah International University, Islamabad.

Insights

Lower limb ergometric training significantly improved ejection fraction and left ventricular dimensions in patients with dilated cardiomyopathy (DCM). This exercise intervention offers a promising non-pharmacological approach for managing DCM.

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Clinical Medicine

Background:

  • Dilated cardiomyopathy (DCM) is a significant cause of heart failure.
  • Current management strategies for DCM often involve pharmacological interventions.
  • Non-pharmacological approaches, such as exercise training, warrant further investigation for their efficacy in DCM.

Purpose of the Study:

  • To assess the impact of lower limb ergometric training on echocardiographic parameters of the left ventricle in patients with DCM.
  • To evaluate the effectiveness of a structured exercise program in improving cardiac function in DCM.

Main Methods:

  • A randomized controlled trial was conducted with 60 clinically stable DCM patients.
  • Patients were allocated to either an 8-week lower limb ergometer exercise program or a control group.
  • Echocardiography was performed pre- and post-intervention to measure left ventricular dimensions and ejection fraction.

Main Results:

  • Statistically significant improvements were observed within the interventional group for ejection fraction (EF), left ventricular internal dimension systole (LVIDS), and left ventricular internal diastolic dimension (LVIDD) (p <0.001).
  • The exercise intervention demonstrated a positive effect on key echocardiographic markers of left ventricular function.
  • No significant adverse events were reported during the study period.

Conclusions:

  • Lower limb ergometric exercise training is effective in enhancing ejection fraction and improving left ventricular dimensions in DCM patients.
  • This form of exercise training represents a viable therapeutic option for improving cardiac function in individuals with dilated cardiomyopathy.
  • The findings support the integration of exercise-based interventions into the management of DCM.
Abstract

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
589
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
526
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
587
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
241
Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
9.2K
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
470