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Updated: Feb 11, 2026

Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function
Published on: August 25, 2022
Modelling Cooperative Tumorigenesis in Drosophila
Helena E Richardson1, Marta Portela2
1Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Abstract:
The development of human metastatic cancer is a multistep process, involving the acquisition of several genetic mutations, tumour heterogeneity, and interactions with the surrounding microenvironment. Due to the complexity of cancer development in mammals, simpler model organisms, such as the vinegar fly, Drosophila melanogaster, are being utilized to provide novel insights into the molecular mechanisms involved. In this review, we highlight recent advances in modelling tumorigenesis using the Drosophila model, focusing on the cooperation of oncogenes or tumour suppressors, and the interaction of mutant cells with the surrounding tissue in epithelial tumour initiation and progression.
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