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[Acupuncture for female depression: a randomized controlled trial].

Jian Liu1, Aiai Wang1, Guangning Nie1

  • 1Department of Gynecology, Guangdong Provincial Hospital of TCM, Guangzhou 510120, China.

Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion
|April 27, 2018
PubMed
Summary

Acupuncture combined with fluoxetine significantly improved depression symptoms in women compared to fluoxetine alone. This integrated approach demonstrated superior efficacy and safety for treating female depression.

Keywords:
acupuncturefemale depressionfluoxetinerandomized controlled trial (RCT)self-rating depression scale (SDS)

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Area of Science:

  • Integrative Medicine
  • Neuroscience
  • Psychiatry

Background:

  • Female depression is a prevalent mental health condition requiring effective treatment.
  • Conventional treatments like fluoxetine offer benefits but may have limitations or side effects.
  • Exploring adjunctive therapies like acupuncture is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy and safety of acupuncture as an add-on therapy for female depression.
  • To compare the effects of acupuncture plus fluoxetine versus sham acupuncture plus fluoxetine.
  • To assess symptom reduction using standardized depression rating scales.

Main Methods:

  • A randomized controlled trial involving 42 female patients diagnosed with depression.
  • Participants received either acupuncture or sham acupuncture alongside fluoxetine for 8 weeks.
  • Depression severity was measured using the Self-Rating Depression Scale (SDS) and Montgomery Asberg Depression Rating Scale (MADRS) at baseline, 4 weeks, and 8 weeks.

Main Results:

  • Both groups showed significant reductions in SDS and MADRS scores after 4 and 8 weeks of treatment.
  • The acupuncture group exhibited significantly greater improvements in SDS and MADRS scores compared to the sham acupuncture group.
  • The acupuncture group reported significantly fewer adverse reactions.

Conclusions:

  • Acupuncture, when combined with fluoxetine, is an effective and safe treatment for female depression.
  • This combination therapy offers enhanced symptom relief and a better safety profile than fluoxetine alone.
  • Acupuncture represents a promising complementary therapy for managing depression in women.