SPECIFICITIES OF ENDOMETRIAL PROLIFERATION/STEM CELL INDEX DISTRIBUTION IN ENDOMETRIOID CARCINOMA OF DIFFERENT GRADE
N Kikalishvili1, R Beriashvili1, T Muzashvili1
1Tbilisi State Medical University, Georgia.
Georgian Medical News
|April 27, 2018
Summary
This study reveals that the proliferative/stem cell index in endometrioid carcinoma increases with malignancy grade and age, particularly in post-menopausal women. This index differs significantly from normal endometrial tissue, highlighting its potential role in cancer development.
Area of Science:
- Gynecologic Oncology
- Stem Cell Biology
- Cancer Pathogenesis
Background:
- Endometrial cancer is a leading cause of gynecologic malignancy in developed nations, with increasing incidence and mortality.
- Understanding endometrial cancer development, particularly the role of endometrial stem cells, is crucial for effective treatment.
- Environmental and lifestyle factors significantly influence endometrial cancer risk.
Purpose of the Study:
- To investigate the distribution of the endometrial proliferative/stem cell index in endometrioid carcinoma of varying malignancy grades.
- To analyze the relationship between this index, tumor grade, and patient menopausal status.
Main Methods:
- Retrospective analysis of histopathology specimens from 60 patients with endometrioid carcinoma (Grades 1-3).
- Immunohistochemistry using proliferation marker Ki67 and stem cell marker CD146.
- Calculation of the proliferative/stem cell index (Ki67-positive cells / CD146-positive cells).
Main Results:
- The proliferative/stem cell index generally increased with endometrioid carcinoma grade (Grade 1: 21.7-25.5; Grade 2: 23.2-27.8; Grade 3: 25.8-29.4).
- In Grades 1 and 2, the index showed a tendency to increase with age, peaking in post-menopausal women, mirroring trends in endometrial hyperplasia.
- In Grade 3, the index remained relatively constant across age groups, and markedly differed from normal endometrial tissue, especially post-menopausally.
Conclusions:
- The proliferative/stem cell index is a potential biomarker for endometrioid carcinoma progression and may be influenced by menopausal status.
- Endometrial stem cell behavior and proliferation dynamics differ significantly in endometrioid carcinoma compared to normal endometrium.
- Further research into endometrial stem cells is warranted to elucidate their role in gynecologic pathologies and develop targeted therapies.
More Related Videos
10:18Exploring the Potential of Mesenchymal Stem Cell Sheet on The Development of Hepatocellular Carcinoma In Vivo
Published on: September 11, 2018
6.3K
08:57Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
2.6K
Related Concept Videos
00:58Embryonic Stem Cells
32.6K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.6K
02:36Cells Coordinate Growth and Proliferation
5.1K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.1K
01:19Graded Potential
7.1K
Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
7.1K
01:33Adult Stem Cells
33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
01:13Induced Pluripotent Stem Cells
28.1K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.1K
02:23Abnormal Proliferation
5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K