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Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies
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Crinkle-Cut Brain Organoids
1MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, UK.
Cell Stem Cell
|May 5, 2018
Abstract
None:
In large mammalian brains, including those of humans, the surface of the cortex is highly folded. How these convolutions form is still unclear, but recent work in Nature Physics by Karzbrun et al. (2018) supports a mechanism involving differential surface swelling combined with internal constraint.
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