Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

83.4K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
83.4K
Acid Attack on Concrete01:21

Acid Attack on Concrete

780
When acids come into contact with concrete, they initiate a chemical reaction that dissolves the hydrated cement paste. This process leads to softening and structural weakening of the concrete. This issue is commonly observed in environments such as chimneys, sewers, and industrial settings. The severity of the damage increases as the pH of the water interacting with the concrete drops below 6.5. In particular, a pH under 4.5 can cause significant concrete damage.
The rate at which hydrogen...
780
Sulfate Attack on Concrete01:29

Sulfate Attack on Concrete

777
Sulfate attack on concrete is a deterioration process characterized by a whitish discoloration beginning at the edges and corners, accompanied by cracking and spalling. This phenomenon occurs when sulfates react with the components of hardened concrete, forming compounds like calcium sulfate and calcium sulfoaluminate which occupy more space than the substances they replace, causing the concrete to expand and disrupt.
Sulfates from sources like soil, groundwater, or industrial effluents...
777
Temperature Dependence on Reaction Rate02:55

Temperature Dependence on Reaction Rate

89.3K
The Collision Theory
Atoms, molecules, or ions must collide before they can react with each other. Atoms must be close together to form chemical bonds. This premise is the basis for a theory that explains many observations regarding chemical kinetics, including factors affecting reaction rates.
The collision theory is based on the postulates that (i) the reaction rate is proportional to the rate of reactant collisions, (ii) the reacting species collide in an orientation allowing contact between...
89.3K
Frequency-dependent Selection01:21

Frequency-dependent Selection

24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K
Drug Dependence01:17

Drug Dependence

1.7K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tuning the tetraarylcyclopentadienones of iron tricarbonyl complexes: effects on transfer hydrogenation and solubility.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Genomic mapping reveals cisplatin disruption of protein phosphorylation signalling genome-wide.

Metallomics : integrated biometal science·2026
Same author

In Vivo Imaging of a Photoactivatable Platinum Prodrug by Metal-Centered Radiolabeling.

Journal of the American Chemical Society·2026
Same author

LIPID MAPS: Powering discovery in lipidomics.

Science signaling·2026
Same author

Chromatography-Free Analysis of Mixtures Using a Two-Dimensional Mass Spectrometry (2DMS)-Enabled Quadrupole Time-of-Flight (QToF) Analyzer.

Analytical chemistry·2026
Same author

A Correlative X‑ray Bioimaging Triad for Metals in Biomedical Research.

Chemical & biomedical imaging·2026
Same journal

From cyclic diaryl λ<sup>3</sup>-bromanes/chloranes to polyfuntionalized biarylsilanes <i>via</i> aryne σ-bonds.

Chemical science·2026
Same journal

Non-equilibrium formation of the elusive dibridged diboranyl (B<sub>2</sub>H<sub>5</sub>) radical and boranes in low-temperature diborane ices.

Chemical science·2026
Same journal

Visible-light-driven ruthenium-catalyzed hydrogenation of manganese nitride complexes to ammonia under ambient conditions.

Chemical science·2026
Same journal

Quantification of mesopore infiltration in a polymer-grafted metal-organic framework.

Chemical science·2026
Same journal

Enhanced and selective oxygen reduction by iron porphyrin with a biguanide residue in the second coordination sphere.

Chemical science·2026
Same journal

Excited-state orbital angular momentum enables all-optical molecular spin coherence.

Chemical science·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.5K

Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes.

Christopher A Wootton1, Carlos Sanchez-Cano1, Andrea F Lopez-Clavijo1

  • 1Department of Chemistry , University of Warwick , Gibbet Hill Road , Coventry CV4 7AL , UK . Email: p.oconnor@warwick.ac.uk ; Email: p.j.sadler@warwick.ac.uk ; ; Fax: +44 (0)24 765 23819 ; Tel: +44 (0)24 76151008 ; Tel: +44 (0)24 765 23818.

Chemical Science
|May 8, 2018
PubMed
Summary
This summary is machine-generated.

Photoactivated platinum(IV) complexes target cancer cells by forming DNA lesions. This study reveals they also interact with peptides, forming oxidized and platinated products, indicating multi-targeting potential against proteins.

More Related Videos

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

14.6K
Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

58.9K

Related Experiment Videos

Last Updated: Feb 11, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.5K
Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

14.6K
Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

58.9K

Area of Science:

  • Inorganic Chemistry
  • Medicinal Chemistry
  • Biochemistry

Background:

  • Octahedral platinum(IV) complexes are stable in the dark but become cytotoxic upon photoactivation.
  • Photoactivation of platinum complexes leads to DNA damage via Pt(II) lesions and radical generation.
  • Proteins are emerging as potential targets for photoactivated platinum anticancer drugs.

Purpose of the Study:

  • To investigate the interaction of photoactivated platinum(IV) complex 1 with neuropeptides.
  • To elucidate the mechanisms of peptide modification by photoactivated platinum complexes.
  • To explore the multi-targeting capabilities of platinum anticancer agents.

Main Methods:

  • High-resolution Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for analyzing peptide reactions.
  • MS/MS analysis with electron-capture dissociation (ECD) to retain platinum complexes during fragmentation.
  • Electron paramagnetic resonance (EPR) spectroscopy with DEPMPO spin-trap to detect radical species.

Main Results:

  • Photoactivated platinum complex 1 reacts with neuropeptides Substance P and [Lys]3-Bombesin.
  • Unexpected oxidized and platinated peptide products were identified.
  • Peptide modification by photoactivated complex 1 is dependent on amino acid sequence and involves radical mechanisms.

Conclusions:

  • Photoactivated platinum(IV) complexes exhibit multi-targeting capabilities beyond DNA.
  • These complexes can interact with peptides and proteins, leading to sequence-dependent platination and oxidation.
  • This study highlights the potential of excited-state platinum anticancer complexes as versatile therapeutic agents.