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GPCRs and Signal Transducers: Interaction Stoichiometry

Vsevolod V Gurevich1, Eugenia V Gurevich1

  • 1Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.

Trends in Pharmacological Sciences
|May 10, 2018
PubMed
Summary

Class A G protein-coupled receptors (GPCRs) were thought to be monomers, but evidence now suggests they interact with signal transducers as single units, not dimers. This review examines GPCR oligomerization and signaling roles.

Keywords:
G proteinsGPCRsGRKsarrestinsoligomerization

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