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The apelin/APJ system plays dual roles, offering therapeutic potential for non-cancerous diseases like insulin resistance and hypertension, but potentially stimulating tumor growth in cancers.

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Area of Science:

  • Biochemistry
  • Physiology
  • Pharmacology

Background:

  • The apelin/APJ system, involving a peptide ligand and a G protein-coupled receptor, is widely distributed and implicated in organ protection.
  • This system's involvement spans numerous physiological processes and disease states.

Purpose of the Study:

  • To review the multifaceted roles of the apelin/APJ system across various diseases.
  • To evaluate the therapeutic potential and diagnostic utility of apelin.

Main Methods:

  • Literature review of studies on the apelin/APJ system.
  • Synthesis of findings related to neurological, metabolic, cardiovascular, respiratory, gastrointestinal, hepatic, renal, and cancerous diseases.

Main Results:

  • Apelin demonstrates therapeutic benefits in non-cancerous conditions such as insulin resistance and hypertension.
  • Conversely, apelin can promote tumor growth and may serve as a diagnostic marker in various cancers.

Conclusions:

  • The apelin/APJ system presents a promising therapeutic target for numerous non-cancerous diseases.
  • Its contrasting roles in cancer necessitate careful consideration for diagnostic and therapeutic applications.